Search results (38 results)

Feb 19 2018 by JEFFERSON R SOUSA, Tecg.º (Biomedical Systems Technology)

Female patient, 28 years in monitoring to control a hyperpigmented lesion in the temporal retina of the right eye.

Photographer: Photographer JEFFERSON ROCHA DE SOUSA, Clinic Dr. Marco Antonio Albhy Oftalmology, Institute Dr. Suel Abujamra São Paulo-Brazil

Imaging device: Retinografo Topcin TRC-NW6S. Mosaic, Flash 25.

Condition/keywords: hyperplasia, hyperplastic retinal pigment epithelium (RPE)

Feb 27 2019 by Lancaster Course in Ophthalmology

Pigmentary glaucoma. Necrosis of the iris pigment epithelium, macro­phages filled with pigment in the iris stroma, and atrophy and hyperplasia of the iris dilator muscle are present (H&E x101).

Condition/keywords: glaucoma, hyperplasia, retinal necrosis

Mar 20 2019 by Lancaster Course in Ophthalmology

Benign reactive lymphoid hyperplasia, showing monotonous infiltrate of mature lymphocytes with occasional mitotic figure (H&E x252).

Condition/keywords: hyperplasia, lymphocytes

Feb 25 2019 by Lancaster Course in Ophthalmology

Benign lymphoid hyperplasia of the conjunctiva may resemble a normal lymph node.

Condition/keywords: conjunctiva, hyperplasia, lymph node

Mar 4 2019 by Lancaster Course in Ophthalmology

Radial perivascular lattice degeneration. The lesion is located at or pos­terior to the equator and is associated with a major vessel. As with a typical lattice there is discontinuity of the internal limiting membrane, a loss of inner retinal layers, an overlying vitreous degeneration, vitreoretinal adhesion at the margin, sclerosis of ves­sels, and retinal pigment epithelial hypertrophy, hyperplasia, and migration into the retina. (E.P. No. 31493)

Condition/keywords: hyperplasia, lattice degeneration, lesion, retinal pigment epithelium, vitreoretinal adhesion, vitreoretinal degeneration

Feb 26 2019 by Lancaster Course in Ophthalmology

"Black sunburst" sign of sickle-cell retinopathy. These are localized le­sions characterized by hypertrophy, hyperplasia, and migration of the retinal pigment epithelium into the retina in a perivascular location. This latter has given the lesion its spiculate ophthalmoscopic and gross appearance.

Condition/keywords: hyperplasia, hypertrophy, sickle cell, spiculate ophthalmoscopic

Feb 26 2019 by Lancaster Course in Ophthalmology

Bassen-Kornzweig syndrome. There is thinning of the outer nuclear layer in the parafoveal area (upper view). In the midperiphery of the retina there is more marked degeneration of the photoreceptor cells, hyperplasia, and migration of the retinal pigment epithelium into the retina in a perivascular location.

Condition/keywords: Bassen-Kornzweig syndrome, hyperplasia, photoreceptor cell, retinal pigment epithelium

Feb 26 2019 by Lancaster Course in Ophthalmology

Reticular degenerative retinoschisis. In this case the process extends posteriorly from the equatorial area to the midperiphery. The gross view (upper left) also shows a band of dark pigmentation due to peripheral retinal pigment epithelial (RPE) hypertrophy, a few areas of paving-stone degeneration within the area of RPE hyper­trophy, and peripheral retinal thinning with focal areas of RPE hyperplasia and migra­tion into the retina.

Condition/keywords: hyperplasia, hypertrophy, retinal pigment epithelium, retinoschisis

Feb 26 2019 by Lancaster Course in Ophthalmology

Disciform macular lesion with marked hyperplasia of RPE (A.F.I.P. No. 797119).

Condition/keywords: disciform macular lesion, hyperplasia, retinal pigment epithelium

Feb 26 2019 by Lancaster Course in Ophthalmology

Hyperplasia of RPE at ora serrata. Fine-stippled, dark pigmentation at the ora serrata is due to pigment epithelial hyperplasia with migration internally (arrow). Histopathologic sections (lower views) show the strands of hyperplastic epithelium in­ternal to the retina and pars plana.

Condition/keywords: ora serrata, retinal pigment epithelium

Jan 24 2024 by Michell Goyal

Fundus photograph of woman with benign uveal lymphoid hyperplasia. The patient had no symptoms and tested 20/20 vision.

Condition/keywords: benign uveal lymphoid hyperplasia, lymphoid hyperplasia, Uveal Lymphoma

May 4 2021 by Priya Rasipuram Chandrasekaran, MBBS, DO, DNB, FRCS

This fundus photo and montage shows pigmentary changes with fibroglial proliferation of the disc and macula in a 36-year-old male following injury with an iron chain. This is usually following a high velocity non-penetrating missile or blast injury categorized as coup injury and can be both direct or indirect. The layers affected are the highly inelastic Bruch’s membrane with choriocapillaris and retinal pigment epithelium in contrast to the highly elastic retina and sclera. The high impact injury causes full thickness defect in the retina, Bruch’s membrane and choroid leading to retraction of the retina and choroid, leaving the intact bare sclera behind. Pathology included defects in the Bruch’s membrane and choroid, and extensive photoreceptor loss with hyperplasia of retinal pigment epithelium. Over the weeks, loose fibrous tissue gets replaced by dense connective tissue leading to scarring between retina and choroid as seen in our patient. The background shows fundus albipunctatus.

Condition/keywords: chorioretinitis sclopetaria

Jan 11 2013 by Alex P. Hunyor, MD

Choroidal rupture, right eye. Note marked RPE hyperplasia

Condition/keywords: choroidal rupture

Sep 7 2019 by Hashim Ali Khan, OD, FAAO

Color fundus montage of a 22-year-old man with congenital hypertrophy of retinal pigment epithelium.

Condition/keywords: bear tracks, congenital hypertrophy of the retinal pigment epithelium (CHRPE), RPE hyperplasia

Feb 2 2021 by Niloofar Piri, MD

43-year-old female with large oval chorioretinal scar in posterior pole with heavy RPE hyperplasia and history of hydrocephalus s/p VP shunt since birth. Findings are consistent with congenital toxoplasmosis.

Condition/keywords: congenital toxoplasmosis

Oct 31 2024 by JULIAN VILLARREAL, MD

60 year old female with an end-stage proliferative macular telangiectasia type 2 with right-angle retinal vessels, manifested as blunted arterioles and venules that connect the superficial and deeper retinal plexus, chorioretinal anastomosis with a fibrovascular scar and a typical retinal pigment hyperplasia , fellow eye showed a focal discontinuity in the ellipsoid zone with a loss of the outer and a disorganization of the inner retinal layers, not involving the foveal center and a non exudative neovascularization

Photographer: Julián Villarreal MD

Imaging device: Zeiss Clarus 700

Condition/keywords: Mac Tel type 2, macular telangiectasia type 2

Nov 27 2020 by Priya Rasipuram Chandrasekaran, MBBS, DO, DNB, FRCS

This is the fundus photo of a 61-year-old male presenting with bilateral gradual loss of vision since 6 months. Bilateral fundus photo shows parafoveal greying with early crystals and retinal pigment hyperplasia around a dilated venule suggestive of type 2 idiopathic parafoveal telangiectasia.

Condition/keywords: parafoveal telangiectasia

Mar 29 2024 by Lucy V Cobbs, M.D.

Fundus autofluorescence photograph of both eyes of a patient with MacTel type 2. Fundus autofluorescence can aid in early diagnosis of disease, showing development of foveal hyperautofluorescence corresponding to deterioration of macular pigment and possible damage to Muller cells. As the disease progresses, RPE hyperplasia may develop and manifests as hypoautofluorescent regions.

Condition/keywords: Mac Tel type 2, retina

Nov 30 2024 by John S. King, MD

Both right and left eyes have symmetrical ring of mottled hypo/hyper AF around the fovea and disc. The HyperAF areas correspond to RPE deposits on OCT as well as areas of blockage on FA, and drusenoid deposits seen on fundus photos 57 yo WF referred for AMD vs Pattern Dystrophy that was diagnosed 10 years ago. Reported some slow progressive vision loss in both eyes for distance and near. Denies nyctalopia or hemeralopia. Background medical history includes HTN, CVD, and DM. No family history of eye problems. Denied pentosan use. Anterior segment showed moderate cataracts (OD>OS). Posterior segment exam showed macular changes and mild NPDR. The macular appearance showed a symmetrical, paramacular ring of fleck-like drusenoid material with some faint focal areas of RPE hyperplasia. Fundus Photos, AF, OCT were performed as well as a gene test. Further questioning showed revealed that her mother and maternal grandmother had both diabetes mellitus and sensorineural hearing loss. The patient developed diabetes in her teens, and some high frequency hearing loss in her early twenties. She had not had a previous genetic test or diagnosis of MIDD. Gene testing is pending for the mitochondrial component. Invitae's retinal panel, which does not include mitochondrial disorders, only showed a variant of uncertain significance, HMCN1. I discussed this case with Dr. Freund, and it is similar to a the case report : Inoue M, Kiss S, Freund KB. MACULAR PIGMENT RINGS AS THE PRESENTING FINDING OF MITOCHONDRIAL MYOPATHY, ENCEPHALOPATHY, LACTIC ACIDOSIS, AND STROKELIKE EPISODES. Retin Cases Brief Rep. 2015 Fall;9(4):260-4. doi: 10.1097/ICB.0000000000000182. PMID: 26200388.

Photographer: Grace Melton and Carley Gunn

Imaging device: Clarus

Condition/keywords: Macular Dystrophy, Maternally Inherited Diabetes and Deafness, MIDD, Mitochondrial Disorder

Nov 30 2024 by John S. King, MD

Both eyes had similar FA findings. There was no dark choroid or signs of leakage. Granular staining around the fovea and disc were present, and the HypoAF areas corresponded to the drusenoid deposits that showed HyperAF. Mild MAs present due to NPDR 57 yo WF referred for AMD vs Pattern Dystrophy that was diagnosed 10 years ago. Reported some slow progressive vision loss in both eyes for distance and near. Denies nyctalopia or hemeralopia. Background medical history includes HTN, CVD, and DM. No family history of eye problems. Denied pentosan use. Anterior segment showed moderate cataracts (OD>OS). Posterior segment exam showed macular changes and mild NPDR. The macular appearance showed a symmetrical, paramacular ring of fleck-like drusenoid material with some faint focal areas of RPE hyperplasia. Fundus Photos, AF, OCT were performed as well as a gene test. Further questioning showed revealed that her mother and maternal grandmother had boith diabetes mellitus and sensorineural hearing loss. The patient developed diabetes in her teens, and some high frequency hearing loss in her early twenties. She had not had a previous genetic test or diagnosis of MIDD. Gene testing is pending for the mitochondrial component. Invitae's retinal panel, which does not include mitochondrial disorders, only showed a variant of uncertain significance, HMCN1. I discussed this case with Dr. Freund, and it is similar to a the case report : Inoue M, Kiss S, Freund KB. MACULAR PIGMENT RINGS AS THE PRESENTING FINDING OF MITOCHONDRIAL MYOPATHY, ENCEPHALOPATHY, LACTIC ACIDOSIS, AND STROKELIKE EPISODES. Retin Cases Brief Rep. 2015 Fall;9(4):260-4. doi: 10.1097/ICB.0000000000000182. PMID: 26200388.

Photographer: Grace Melton and Carley Gunn

Imaging device: Clarus

Condition/keywords: Macular Dystrophy, Maternally Inherited Diabetes and Deafness, MIDD, Mitochondrial Disorder

Nov 30 2024 by John S. King, MD

Both the right and left Eye have fairly symmetrical, extrafoveal drusenoid-like flecks and focal and faint areas of RPE hyperplasia (in addition to mild NPDR and PPA) 57 yo WF referred for AMD vs Pattern Dystrophy that was diagnosed 10 years ago. Reported some slow progressive vision loss in both eyes for distance and near. Denies nyctalopia or hemeralopia. Background medical history includes HTN, CVD, and DM. No family history of eye problems. Denied pentosan use. Anterior segment showed moderate cataracts (OD>OS). Posterior segment exam showed macular changes and mild NPDR. The macular appearance showed a symmetrical, paramacular ring of fleck-like drusenoid material with some faint focal areas of RPE hyperplasia. Fundus Photos, AF, OCT were performed as well as a gene test. Further questioning showed revealed that her mother and maternal grandmother had both diabetes mellitus and sensorineural hearing loss. The patient developed diabetes in her teens, and some high frequency hearing loss in her early twenties. She had not had a previous genetic test or diagnosis of MIDD. Gene testing is pending for the mitochondrial component. Invitae's retinal panel, which does not include mitochondrial disorders, only showed a variant of uncertain significance, HMCN1. I discussed this case with Dr. Freund, and it is similar to a the case report : Inoue M, Kiss S, Freund KB. MACULAR PIGMENT RINGS AS THE PRESENTING FINDING OF MITOCHONDRIAL MYOPATHY, ENCEPHALOPATHY, LACTIC ACIDOSIS, AND STROKELIKE EPISODES. Retin Cases Brief Rep. 2015 Fall;9(4):260-4. doi: 10.1097/ICB.0000000000000182. PMID: 26200388.

Photographer: Grace Melton and Carley Gunn

Imaging device: Clarus

Condition/keywords: Macular Dystrophy, Maternally Inherited Diabetes and Deafness, MIDD, Mitochondrial Disorder

Nov 30 2024 by John S. King, MD

OCT shows mild RPE deposit inferiorly (corresponds to area of FA blockage and HyperAF) and a focal area of iRORA with loss of EZ more superiorly (possibly due to regression of RPE deposit). No choroidal thickening (like in pachychoroid pigment epitheliopathy or cscr) 57 yo WF referred for AMD vs Pattern Dystrophy that was diagnosed 10 years ago. Reported some slow progressive vision loss in both eyes for distance and near. Denies nyctalopia or hemeralopia. Background medical history includes HTN, CVD, and DM. No family history of eye problems. Denied pentosan use. Anterior segment showed moderate cataracts (OD>OS). Posterior segment exam showed macular changes and mild NPDR. The macular appearance showed a symmetrical, paramacular ring of fleck-like drusenoid material with some faint focal areas of RPE hyperplasia. Fundus Photos, AF, OCT were performed as well as a gene test. Further questioning showed revealed that her mother and maternal grandmother had both diabetes mellitus and sensorineural hearing loss. The patient developed diabetes in her teens, and some high frequency hearing loss in her early twenties. She had not had a previous genetic test or diagnosis of MIDD. Gene testing is pending for the mitochondrial component. Invitae's retinal panel, which does not include mitochondrial disorders, only showed a variant of uncertain significance, HMCN1. I discussed this case with Dr. Freund, and it is similar to a the case report : Inoue M, Kiss S, Freund KB. MACULAR PIGMENT RINGS AS THE PRESENTING FINDING OF MITOCHONDRIAL MYOPATHY, ENCEPHALOPATHY, LACTIC ACIDOSIS, AND STROKELIKE EPISODES. Retin Cases Brief Rep. 2015 Fall;9(4):260-4. doi: 10.1097/ICB.0000000000000182. PMID: 26200388.

Photographer: Grace Melton and Carley Gunn

Imaging device: Zeiss Cirrus

Condition/keywords: Macular Dystrophy, Maternally Inherited Diabetes and Deafness, MIDD, Mitochondrial Disorder

Nov 30 2024 by John S. King, MD

Magnified section of radial scan through the left eye showing a focal nodular RPE deposit that corresponds to a focal drusenoid deposit in temporal macula, that HypoFLs and HyperAFs. Choroid not significantly thickened or thinned, and the nodular thickening may be just above a large outer choroid vessel?) 57 yo WF referred for AMD vs Pattern Dystrophy that was diagnosed 10 years ago. Reported some slow progressive vision loss in both eyes for distance and near. Denies nyctalopia or hemeralopia. Background medical history includes HTN, CVD, and DM. No family history of eye problems. Denied pentosan use. Anterior segment showed moderate cataracts (OD>OS). Posterior segment exam showed macular changes and mild NPDR. The macular appearance showed a symmetrical, paramacular ring of fleck-like drusenoid material with some faint focal areas of RPE hyperplasia. Fundus Photos, AF, OCT were performed as well as a gene test. Further questioning showed revealed that her mother and maternal grandmother had both diabetes mellitus and sensorineural hearing loss. The patient developed diabetes in her teens, and some high frequency hearing loss in her early twenties. She had not had a previous genetic test or diagnosis of MIDD. Gene testing is pending for the mitochondrial component. Invitae's retinal panel, which does not include mitochondrial disorders, only showed a variant of uncertain significance, HMCN1. I discussed this case with Dr. Freund, and it is similar to a the case report : Inoue M, Kiss S, Freund KB. MACULAR PIGMENT RINGS AS THE PRESENTING FINDING OF MITOCHONDRIAL MYOPATHY, ENCEPHALOPATHY, LACTIC ACIDOSIS, AND STROKELIKE EPISODES. Retin Cases Brief Rep. 2015 Fall;9(4):260-4. doi: 10.1097/ICB.0000000000000182. PMID: 26200388.

Photographer: Grace Melton and Carley Gunn

Imaging device: Zeiss Cirrus

Condition/keywords: Macular Dystrophy, Maternally Inherited Diabetes and Deafness, MIDD, Mitochondrial Disorder

Nov 30 2024 by John S. King, MD

Both right and left eyes have symmetrical ring of mottled hypo/hyper AF around the fovea and disc. The HyperAF areas correspond to RPE deposits on OCT as well as areas of blockage on FA, and drusenoid deposits seen on fundus photos. Disc drusen in right eye present as HyperAF spot 57 yo WF referred for AMD vs Pattern Dystrophy that was diagnosed 10 years ago. Reported some slow progressive vision loss in both eyes for distance and near. Denies nyctalopia or hemeralopia. Background medical history includes HTN, CVD, and DM. No family history of eye problems. Denied pentosan use. Anterior segment showed moderate cataracts (OD>OS). Posterior segment exam showed macular changes and mild NPDR. The macular appearance showed a symmetrical, paramacular ring of fleck-like drusenoid material with some faint focal areas of RPE hyperplasia. Fundus Photos, AF, OCT were performed as well as a gene test. Further questioning showed revealed that her mother and maternal grandmother had both diabetes mellitus and sensorineural hearing loss. The patient developed diabetes in her teens, and some high frequency hearing loss in her early twenties. She had not had a previous genetic test or diagnosis of MIDD. Gene testing is pending for the mitochondrial component. Invitae's retinal panel, which does not include mitochondrial disorders, only showed a variant of uncertain significance, HMCN1. I discussed this case with Dr. Freund, and it is similar to a the case report : Inoue M, Kiss S, Freund KB. MACULAR PIGMENT RINGS AS THE PRESENTING FINDING OF MITOCHONDRIAL MYOPATHY, ENCEPHALOPATHY, LACTIC ACIDOSIS, AND STROKELIKE EPISODES. Retin Cases Brief Rep. 2015 Fall;9(4):260-4. doi: 10.1097/ICB.0000000000000182. PMID: 26200388.

Photographer: Grace Melton and Carley Gunn

Imaging device: Clarus

Condition/keywords: Macular Dystrophy, Maternally Inherited Diabetes and Deafness, MIDD, Mitochondrial Disorder

Nov 30 2024 by John S. King, MD

Both eyes had similar FA findings. There was no dark choroid or signs of leakage. Granular staining around the fovea and disc were present, and the HypoAF areas corresponded to the drusenoid deposits that showed HyperAF. Mild MAs present due to NPDR 57 yo WF referred for AMD vs Pattern Dystrophy that was diagnosed 10 years ago. Reported some slow progressive vision loss in both eyes for distance and near. Denies nyctalopia or hemeralopia. Background medical history includes HTN, CVD, and DM. No family history of eye problems. Denied pentosan use. Anterior segment showed moderate cataracts (OD>OS). Posterior segment exam showed macular changes and mild NPDR. The macular appearance showed a symmetrical, paramacular ring of fleck-like drusenoid material with some faint focal areas of RPE hyperplasia. Fundus Photos, AF, OCT were performed as well as a gene test. Further questioning showed revealed that her mother and maternal grandmother had boith diabetes mellitus and sensorineural hearing loss. The patient developed diabetes in her teens, and some high frequency hearing loss in her early twenties. She had not had a previous genetic test or diagnosis of MIDD. Gene testing is pending for the mitochondrial component. Invitae's retinal panel, which does not include mitochondrial disorders, only showed a variant of uncertain significance, HMCN1. I discussed this case with Dr. Freund, and it is similar to a the case report : Inoue M, Kiss S, Freund KB. MACULAR PIGMENT RINGS AS THE PRESENTING FINDING OF MITOCHONDRIAL MYOPATHY, ENCEPHALOPATHY, LACTIC ACIDOSIS, AND STROKELIKE EPISODES. Retin Cases Brief Rep. 2015 Fall;9(4):260-4. doi: 10.1097/ICB.0000000000000182. PMID: 26200388.

Photographer: Grace Melton and Carley Gunn

Imaging device: Clarus

Condition/keywords: Macular Dystrophy, Maternally Inherited Diabetes and Deafness, MIDD, Mitochondrial Disorder