Amelanotic Melanoma

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File number: 133550

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    Appears in
    Miscellaneous
    Condition/keywords
    amelanotic melanoma
    Photographer
    @eyemissu2
    Imaging device
    Fundus camera
    California ICG OPTOS
    Description
    This FAF image reveals a hypoautofluorescent mass with areas of dense hyperautofluorescent stippling—a classic pattern suggestive of an amelanotic choroidal melanoma. Amelanotic melanoma is a rare variant of uveal melanoma, accounting for only a minority of cases. Unlike pigmented melanomas, these lesions lack melanin, making them more challenging to detect on conventional color fundus imaging. FAF Characteristics: • Central hypoautofluorescence: due to loss or compression of the RPE • Peripheral hyperautofluorescent speckling: consistent with lipofuscin accumulation or RPE disruption • Often associated with subretinal fluid or orange pigment seen clinically Location: Juxtapapillary, with potential optic nerve involvement—a factor that complicates both diagnosis and

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