Thomas A. Ciulla, MD, MBA, FASRS » Multifocal Best Disease

This 68 year old man was referred with a maculopathy but with normal visual acuity. He is thought to have multifocal Best Disease; there is no evidence of inflammation or uveitis and no history of cancer. Macular exam reveals yellow subretinal pigment clumping in each macula, including the foveal area. OCT shows moderate hyper-reflective PED, with no evidence of subretinal fluid or macular edema. Angiography reveals blocking defects due to pigment clumping with no evidence of CNVM.