McGill University Health Centre » VogtKoyanagiHarada Disease

Dec 13 2019 by McGill University Health Centre

An 45-year-old Asian descendant woman with poliosis and periocular vitiligo. Histopathology shows thickening of the choroid and chronic granulomatous choroiditis involving the choriocapillaris, typical of VKH.

Photographer: Miguel N. Burnier, McGill University Health Center-McGill University Ocular Pathology & Translational Research Laboratory

Imaging device: Zeiss

Condition/keywords: depigmentation of the fundus, histopathology, Vogt-Koyanagi-Harada

Dec 13 2019 by McGill University Health Centre

Fundus photograph of an 45-year-old Asian descendant woman with poliosis and periocular vitiligo. Fundoscopy reveals a large area of depigmentation of the fundus and a retinal detachment .

Photographer: Miguel N. Burnier, McGill University Health Center-McGill University Ocular Pathology & Translational Research Laboratory

Imaging device: Fundoscopy

Condition/keywords: depigmentation of the fundus, Vogt-Koyanagi-Harada

May 18 2020 by McGill University Health Centre

VKH disease is an autoimmune condition that causes bilateral chronic granulomatous panuveitis, and extraocular manifestations in the central nervous system, auditory system, and integument. VKH disease is twice as prevalent in women than men, and is believed to be associated with specific human leukocyte antigen (HLA) types, suggesting a possible hereditary component. The exact cause of VKH disease, however, remains unclear. In (A), an enucleation specimen shows a retinal detachment and a scleral buckle (*).

Condition/keywords: scleral buckle, Vogt-Koyanagi-Harada

May 18 2020 by McGill University Health Centre

VKH disease is an autoimmune condition that causes bilateral chronic granulomatous panuveitis, and extraocular manifestations in the central nervous system, auditory system, and integument. VKH disease is twice as prevalent in women than men, and is believed to be associated with specific human leukocyte antigen (HLA) types, suggesting a possible hereditary component. The exact cause of VKH disease, however, remains unclear. Image (B) shows several aggregate RPE cells and histiocytes, called Dalen–Fuchs nodules (arrows)

Condition/keywords: Dalen-Fuchs nodules, enucleation, Vogt-Koyanagi-Harada

May 18 2020 by McGill University Health Centre

This enucleation specimen shows complete distortion of the anterior chamber. The iris and the chamber are completely replaced by a whitish mass corresponding to inflammatory exudate. The eye is aphakic and the retina is completely detached from the choroid, although it is attached anteriorly to the mass. Note the proteinaceous exudate beneath the retina (arrowheads).

Condition/keywords: chronic, Vogt-Koyanagi-Harada