Pathophysiology of Anomalous PVD

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File number: 62213

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    Appears in
    Vitreous
    Condition/keywords
    pathology, peripheral vascular disease (PVD)
    Description
    This unifying concept of vitreo-retinopathies hypothesizes that the pathogenesis of several vitreoretinal diseases that were previously considered very disparate, are actually all manifestations of the same underlying pathophysiology – anomalous PVD. Note that vitreo-papillary adhesion (VPA) and traction can cause primary optic neuropathy, but might also play a role in facilitating/promoting cell migration and proliferation during pathologic neovascularization of the optic disc. Further, VPA seems to alter the vector of tangential forces exerted by a membrane, in some cases full-thickness posterior vitreous cortex and in some cases the outer layer of the posterior vitreous cortex left attached to the macula after vitreoschisis. While not all cases of macular holes have vitreoschisis, they feature vitreomacular adhesion and traction almost always with VPA. [From Sebag J: Anomalous PVD – a unifying concept in vitreo-retinal diseases. Graefe’s Arch Clin Exp Ophthalmol 2004;242:690-8 and Sebag J, Niemeyer M, Koss M: Anomalous PVD and vitreoschisis. In: Vitreous – in Health & Disease (J. Sebag, ed.) Springer, New York, 2014, pg. 252; image © Springer Nature, reprinted with permission]

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