Search results (63 results)

Apr 17 2025 by Gustavo Uriel Fonseca Aguirre

Top (B-mode): The longitudinal scan reveals a hyperechoic, flat, and well-demarcated macular lesion with posterior acoustic shadowing, pathognomonic for choroidal osteoma. Bottom (A-mode): Standardized tracing shows a tall initial spike (100% reflectivity) at the tumor surface with rapid decay to acoustic silence, confirming sound absorption by calcified tissue. This pattern remains unchanged at variable gain settings.

Photographer: Gustavo U. Fonseca Aguirre, Hospital Conde de Valenciana, Ciudad de México

Condition/keywords: choroidal osteoma, macular choroidal osteoma

Dec 10 2020 by McGill University Health Centre

Postmortem eyes from 101-year-old female. Past clinical history includes a poor vision for many years due to macular degeneration. The last visual acuity test recorded 6/15 OD and 6/6 OS. IOP 14 and 18 torr OS. Histopathology: Disclosed and yellow 2x2mm macular lesion. Microscopic examination: elevated placoid macular lesion with overlying pigment granules. Electron microscopy examination: pigment granules with abundant lipofuscin and melanolysosomes, photoreceptor cells markedly attenuated (less degenerated at the periphery) Numerous calcified drusen throughout the retina particularly in the posterior pole. RPE lipofuscin content is elevated in Best’s dystrophy. The extractability of the PRE lipofuscin fluorophores is reduced (it is normal during senescence). The defect in Best’s dystrophy accelerates this age related change in lipofuscin.

Condition/keywords: Best vitelliform macular dystrophy (BVMD), histopathology, pathology

Dec 10 2020 by McGill University Health Centre

Postmortem eyes from 101-year-old female. Past clinical history includes a poor vision for many years due to macular degeneration. The last visual acuity test recorded 6/15 OD and 6/6 OS. IOP 14 and 18 torr OS. Histopathology: Disclosed and yellow 2x2mm macular lesion. Microscopic examination: elevated placoid macular lesion with overlying pigment granules. Electron microscopy examination: pigment granules with abundant lipofuscin and melanolysosomes, photoreceptor cells markedly attenuated (less degenerated at the periphery) Numerous calcified drusen throughout the retina particularly in the posterior pole. RPE lipofuscin content is elevated in Best’s dystrophy. The extractability of the PRE lipofuscin fluorophores is reduced (it is normal during senescence). The defect in Best’s dystrophy accelerates this age related change in lipofuscin.

Condition/keywords: Best vitelliform macular dystrophy (BVMD), histopathology, pathology

Dec 10 2020 by McGill University Health Centre

Postmortem eyes from 101-year-old female. Past clinical history includes a poor vision for many years due to macular degeneration. The last Visual acuity test recorded 6/15 OD and 6/6 OS. IOP 14 and 18 torr OS. Histopathology: Disclosed and yellow 2x2mm macular lesion. Microscopic examination: elevated placoid macular lesion with overlying pigment granules. Electron microscopy examination: pigment granules with abundant lipofuscin and melanolysosomes, photoreceptor cells markedly attenuated (less degenerated at the periphery) Numerous calcified drusen throughout the retina particularly in the posterior pole. RPE lipofuscin content is elevated in Best’s dystrophy. The extractability of the PRE lipofuscin fluorophores is reduced (it is normal during senescence). The defect in Best’s dystrophy accelerates this age related change in lipofuscin.

Condition/keywords: Best vitelliform macular dystrophy (BVMD), histopathology, pathology

Dec 10 2020 by McGill University Health Centre

Postmortem eyes from 101-year-old female. Past clinical history includes a poor vision for many years due to macular degeneration. The last visual acuity test recorded 6/15 OD and 6/6 OS. IOP 14 and 18 torr OS. Histopathology: Disclosed and yellow 2x2mm macular lesion. Microscopic examination: elevated placoid macular lesion with overlying pigment granules. Electron microscopy examination: pigment granules with abundant lipofuscin and melanolysosomes, photoreceptor cells markedly attenuated (less degenerated at the periphery) Numerous calcified drusen throughout the retina particularly in the posterior pole. RPE lipofuscin content is elevated in Best’s dystrophy. The extractability of the PRE lipofuscin fluorophores is reduced (it is normal during senescence). The defect in Best’s dystrophy accelerates this age related change in lipofuscin.

Condition/keywords: Best vitelliform macular dystrophy (BVMD), fundus photograph

Jan 21 2020 by Pierre-Henry Gabrielle, MD

Coupled OCT B-scan and IR imaging of a 17-year-old man with combined hamartomas of the retina and retinal pigment epithelium (CHRRPE) at the posterior pole of the left eye. One can see a highly reflective elevated macular lesion with hyporeflective shadowing of the underlying tissue and obscuration of the normal retinal layers.

Photographer: Pierre-Henry Gabrielle, Ophthalmology department, Dijon University Hospital, France

Imaging device: Heidelberg Spectralis

Condition/keywords: combined hamartoma, optical coherence tomography (OCT)

Jan 21 2020 by Pierre-Henry Gabrielle, MD

Coupled OCT B-scan and IR imaging of a 17-year-old man with Combined hamartomas of the retina and retinal pigment epithelium (CHRRPE) at the posterior pole of the left eye. One can see a highly reflective elevated macular lesion with hyporeflective shadowing of the underlying tissue and obscuration of the normal retinal layers.

Photographer: Pierre-Henry Gabrielle, Ophthalmology department, Dijon University Hospital, France

Imaging device: Heidelberg Spectralis

Condition/keywords: combined hamartoma, optical coherence tomography (OCT)

Dec 18 2019 by Yoshihiro Yonekawa, MD, FASRS

Widefield fundus image of a teenage girl's right eye with an inactive congenital toxoplasmosis macular lesion. Her vision is 20/400 in this eye.

Photographer: Netanya Lerner, COA, Wills Eye Hospital/Mid Atlantic Retina

Imaging device: Optos California

Condition/keywords: congenital toxoplasmosis, pediatric retina

May 7 2019 by William Ensor

A 37-year-old female presented with a two-week history of vision loss in the right eye. She experienced a flu-like illness including rash on the hands, feet, and mouth 2 days prior to her vision change. Her 3-year-old son had a similar illness diagnosed as hand, foot, and mouth disease by his pediatrician one week prior. Her visual acuity was 20/150 of the right eye, and 20/20 of the left eye. On dilated fundus examination, the left eye was unremarkable; the right eye revealed a circular, variably pigmented lesion of the macula. OCT imaging showed areas of RPE loss and clumping, with overlying loss of the photoreceptor layer. Fluorescein angiography showed central and peripheral hyperfluorescence consistent with window defect, and blockage in area of RPE loss. No treatment was initiated at this time. The patient returned 10 days later; her visual acuity improved to 20/50 in the right eye. Dilated fundus exam showed increased pigmentation of the macular lesion. OCT of the right eye showed further RPE clumping without recovery of the photoreceptor layer, despite her improved visual acuity.

Condition/keywords: unilateral acute idiopathic maculopathy

May 7 2019 by William Ensor

A 37-year-old female presented with a two-week history of vision loss in the right eye. She experienced a flu-like illness including rash on the hands, feet, and mouth 2 days prior to her vision change. Her 3-year-old son had a similar illness diagnosed as hand, foot, and mouth disease by his pediatrician one week prior. Her visual acuity was 20/150 of the right eye, and 20/20 of the left eye. On dilated fundus examination, the left eye was unremarkable; the right eye revealed a circular, variably pigmented lesion of the macula. OCT imaging showed areas of RPE loss and clumping, with overlying loss of the photoreceptor layer. Fluorescein angiography showed central and peripheral hyperfluorescence consistent with window defect, and blockage in area of RPE loss. No treatment was initiated at this time. The patient returned 10 days later; her visual acuity improved to 20/50 in the right eye. Dilated fundus exam showed increased pigmentation of the macular lesion. OCT of the right eye showed further RPE clumping without recovery of the photoreceptor layer, despite her improved visual acuity.

Condition/keywords: unilateral acute idiopathic maculopathy

May 7 2019 by William Ensor

A 37-year-old female presented with a two-week history of vision loss in the right eye. She experienced a flu-like illness including rash on the hands, feet, and mouth 2 days prior to her vision change. Her 3-year-old son had a similar illness diagnosed as hand, foot, and mouth disease by his pediatrician one week prior. Her visual acuity was 20/150 of the right eye, and 20/20 of the left eye. On dilated fundus examination, the left eye was unremarkable; the right eye revealed a circular, variably pigmented lesion of the macula. OCT imaging showed areas of RPE loss and clumping, with overlying loss of the photoreceptor layer. Fluorescein angiography showed central and peripheral hyperfluorescence consistent with window defect, and blockage in area of RPE loss. No treatment was initiated at this time. The patient returned 10 days later; her visual acuity improved to 20/50 in the right eye. Dilated fundus exam showed increased pigmentation of the macular lesion. OCT of the right eye showed further RPE clumping without recovery of the photoreceptor layer, despite her improved visual acuity.

Condition/keywords: unilateral acute idiopathic maculopathy

May 7 2019 by William Ensor

A 37-year-old female presented with a two-week history of vision loss in the right eye. She experienced a flu-like illness including rash on the hands, feet, and mouth 2 days prior to her vision change. Her 3-year-old son had a similar illness diagnosed as hand, foot, and mouth disease by his pediatrician one week prior. Her visual acuity was 20/150 of the right eye, and 20/20 of the left eye. On dilated fundus examination, the left eye was unremarkable; the right eye revealed a circular, variably pigmented lesion of the macula. OCT imaging showed areas of RPE loss and clumping, with overlying loss of the photoreceptor layer. Fluorescein angiography showed central and peripheral hyperfluorescence consistent with window defect, and blockage in area of RPE loss. No treatment was initiated at this time. The patient returned 10 days later; her visual acuity improved to 20/50 in the right eye. Dilated fundus exam showed increased pigmentation of the macular lesion. OCT of the right eye showed further RPE clumping without recovery of the photoreceptor layer, despite her improved visual acuity.

Condition/keywords: unilateral acute idiopathic maculopathy

May 7 2019 by William Ensor

A 37-year-old female presented with a two-week history of vision loss in the right eye. She experienced a flu-like illness including rash on the hands, feet, and mouth 2 days prior to her vision change. Her 3-year-old son had a similar illness diagnosed as hand, foot, and mouth disease by his pediatrician one week prior. Her visual acuity was 20/150 of the right eye, and 20/20 of the left eye. On dilated fundus examination, the left eye was unremarkable; the right eye revealed a circular, variably pigmented lesion of the macula. OCT imaging showed areas of RPE loss and clumping, with overlying loss of the photoreceptor layer. Fluorescein angiography showed central and peripheral hyperfluorescence consistent with window defect, and blockage in area of RPE loss. No treatment was initiated at this time. The patient returned 10 days later; her visual acuity improved to 20/50 in the right eye. Dilated fundus exam showed increased pigmentation of the macular lesion. OCT of the right eye showed further RPE clumping without recovery of the photoreceptor layer, despite her improved visual acuity.

Condition/keywords: unilateral acute idiopathic maculopathy

May 7 2019 by William Ensor

A 37-year-old female presented with a two-week history of vision loss in the right eye. She experienced a flu-like illness including rash on the hands, feet, and mouth 2 days prior to her vision change. Her 3-year-old son had a similar illness diagnosed as hand, foot, and mouth disease by his pediatrician one week prior. Her visual acuity was 20/150 of the right eye, and 20/20 of the left eye. On dilated fundus examination, the left eye was unremarkable; the right eye revealed a circular, variably pigmented lesion of the macula. OCT imaging showed areas of RPE loss and clumping, with overlying loss of the photoreceptor layer. Fluorescein angiography showed central and peripheral hyperfluorescence consistent with window defect, and blockage in area of RPE loss. No treatment was initiated at this time. The patient returned 10 days later; her visual acuity improved to 20/50 in the right eye. Dilated fundus exam showed increased pigmentation of the macular lesion. OCT of the right eye showed further RPE clumping without recovery of the photoreceptor layer, despite her improved visual acuity.

Condition/keywords: unilateral acute idiopathic maculopathy

May 7 2019 by William Ensor

A 37-year-old female presented with a two-week history of vision loss in the right eye. She experienced a flu-like illness including rash on the hands, feet, and mouth 2 days prior to her vision change. Her 3-year-old son had a similar illness diagnosed as hand, foot, and mouth disease by his pediatrician one week prior. Her visual acuity was 20/150 of the right eye, and 20/20 of the left eye. On dilated fundus examination, the left eye was unremarkable; the right eye revealed a circular, variably pigmented lesion of the macula. OCT imaging showed areas of RPE loss and clumping, with overlying loss of the photoreceptor layer. Fluorescein angiography showed central and peripheral hyperfluorescence consistent with window defect, and blockage in area of RPE loss. No treatment was initiated at this time. The patient returned 10 days later; her visual acuity improved to 20/50 in the right eye. Dilated fundus exam showed increased pigmentation of the macular lesion. OCT of the right eye showed further RPE clumping without recovery of the photoreceptor layer, despite her improved visual acuity.

Condition/keywords: unilateral acute idiopathic maculopathy

Apr 8 2019 by Gary R. Cook, MD, FACS

Right eye of a 23-year-old male with congenital toxoplasmosis OD; view of macular lesion.

Condition/keywords: congenital toxoplasmosis, inactive toxoplasmosis, macular scar, ocular toxoplasmosis

Apr 8 2019 by Gary R. Cook, MD, FACS

38-year-old white male with atrophic macular lesion OS secondary to Stargardt's disease; V.A. = 20/200

Imaging device: Topcon VT-50

Condition/keywords: atrophic central lesion, Stargardt disease

Apr 8 2019 by Gary R. Cook, MD, FACS

38-year-old white male with typical atrophic macular lesion OD secondary to Stargardt's disease; V.A. = 20/200

Imaging device: Topcon VT-50

Condition/keywords: atrophic central lesion, Stargardt disease

Apr 2 2019 by Gary R. Cook, MD, FACS

10-year old white male with stellate macular lesion OS due to juvenile retinoschisis.

Condition/keywords: juvenile retinoschisis, retinoschisis, stellate maculopathy

Apr 2 2019 by Gary R. Cook, MD, FACS

10-year old white male with stellate macular lesion OD secondary to juvenile retinoschisis; V.A. = 20/100

Condition/keywords: juvenile retinoschisis, retinoschisis, stellate maculopathy

Feb 26 2019 by Lancaster Course in Ophthalmology

Coats' disease with disciform macular lesion. There is accumulation of periodic acid-Schiff-positive staining material within and under the retina peripherally (upper left), in association with telangiectatic retinal vessels (arrow , upper right) . A fibrous nodule is present under the retina in the macular area (lower views). The lami­nated appearance and partial pigmentation suggest that this fibrous nodule is in part derived from hyperplastic retinal pigment epithelium (lower right).

Condition/keywords: Coats' disease, disciform macular lesion

Feb 26 2019 by Lancaster Course in Ophthalmology

Disciform macular lesion with marked hyperplasia of RPE (A.F.I.P. No. 797119).

Condition/keywords: disciform macular lesion, hyperplasia, retinal pigment epithelium

Feb 26 2019 by Lancaster Course in Ophthalmology

Macular disciform lesion in a 73-year-old man with angioid streaks and pseudoxanthoma elasticum. The streak is subjacent to the scar and is the point at which choroidal vessels (arrows) extend internally. The same streak closer to the disc is shown in the lower right view.

Condition/keywords: angioid streaks, disciform macular lesion, pseudoxanthoma elasticum (PXE)

Feb 26 2019 by Lancaster Course in Ophthalmology

Macular disciform lesion in the ocular histoplasmosis syndrome. Note choroidal scar with vessels (arrow) extending through a break in Bruch's membrane.

Condition/keywords: Bruch's membrane, disciform macular lesion, ocular histoplasmosis syndrome (OHS)

Feb 26 2019 by Lancaster Course in Ophthalmology

Central areolar choroidal sclerosis. Macular lesions in three generations of the same family. (Upper three views courtesy of R. E. Carr, M.D. ). Histopathologic study shows loss of retinal pigment epithelium and photoreceptor cells but with a preservation of choriocapillaris in some areas. (Middle and lower views courtesy of Andrew Ferry, M.D.)

Condition/keywords: central areolar choroidal dystrophy (CACD), photoreceptor cell, retinal pigment epithelium