Lancaster Course in Ophthalmology » Unit 01 Ocular Inflammation

Feb 14 2019 by Lancaster Course in Ophthalmology

Polymorphonuclear leukocytes (PMNs) marginated around a vein wall and passing into the tissue. Limbal episclera is shown after a penetrating injury. (H&E stain)

Condition/keywords: limbal episclera, polymorphonuclear leukocytes (PMNs)

Feb 14 2019 by Lancaster Course in Ophthalmology

Dilated choroidal veins in early inflammation. (H&E stain).

Condition/keywords: choroidal vein, inflammation

Feb 14 2019 by Lancaster Course in Ophthalmology

Pink network of fibrin strands lying over the iris in recurrent iritis ("fibrin- o s exudate"). (H&E stain)

Condition/keywords: fibrin, iris, iritis

Feb 19 2019 by Lancaster Course in Ophthalmology

Electron micrograph of PMNs adherent to a vein wall. One is actively penetrating the endothelial junctions (arrow). Five others are already under the endo­thelium.

Condition/keywords: electron micrograph, endothelium, polymorphonuclear leukocytes (PMNs)

Feb 19 2019 by Lancaster Course in Ophthalmology

Pus (hypopyon) in the angle of the anterior chamber, secondary to a bactecorneal ulcer. (H&E stain)

Condition/keywords: bactecorneal ulcer, hypopyon, pus

Feb 19 2019 by Lancaster Course in Ophthalmology

PMNs invading and digesting the lens cortex in a suppurative endophthal­mitis. (H&E stain)

Condition/keywords: endophthalmitis, lens cortex, polymorphonuclear leukocytes (PMNs)

Feb 19 2019 by Lancaster Course in Ophthalmology

Upper: Bilobed eosinophils. Lower: Large mast cell identified by its pur­ple granules. Both views are from scrapings in allergic conjunctivitis. (Giemsa stain)

Condition/keywords: cell, conjunctivitis, eosinophils

Feb 19 2019 by Lancaster Course in Ophthalmology

Macrophages with indented and folded nuclei clinging to zonules in a patient with chronic uveitis. (H&E stain)

Condition/keywords: macrophages, uveitis, zonules

Feb 19 2019 by Lancaster Course in Ophthalmology

Macrophages swollen with phagocytosed ghost red cells following hemorrhage in the vitreous after trauma. (H&E stain)

Condition/keywords: macrophages, phagocytosed, vitreous

Feb 19 2019 by Lancaster Course in Ophthalmology

Retinal granuloma beside a vessel in sarcoid. The sharply demarcated nodule is composed of large, pink, epithelioid cells with a few scattered lymphocytes. (H&E stain)

Condition/keywords: epithelioid cells, granuloma, lymphocytes, sarcoid

Feb 19 2019 by Lancaster Course in Ophthalmology

Cross-sections of two cilia implanted in the anterior chamber by trauma. Giant cells and scar surround each one. (H&E stain)

Condition/keywords: anterior chamber, cilia, giant cell, scar, trauma

Feb 19 2019 by Lancaster Course in Ophthalmology

Seven small lymphocytes with a scanty rim of blue cytoplasm amid dead cells in chronic conjunctivitis. (Giemsa stain)

Condition/keywords: conjunctivitis, cytoplasm, lymphocytes

Feb 19 2019 by Lancaster Course in Ophthalmology

Plasma cells showing eccentric cartwheel nucleus and paranuclear clear zone, from a pyogenic granuloma of the conjunctiva. (H&E stain)

Condition/keywords: conjunctiva, granuloma, perinuclear clear zone, plasma cells

Feb 19 2019 by Lancaster Course in Ophthalmology

Russell body in center of field appears as a multilobed, pink body with faint nuclear remnants, while small lymphocytes and plasma cells are seen on the left, in chronic uveitis following herpes zoster. (H&E stain)

Condition/keywords: chronic uveitis, Herpes zoster, lymphocytes

Feb 19 2019 by Lancaster Course in Ophthalmology

Granulation tissue in the wall of a vitreous abscess. (H&E stain)

Condition/keywords: abscess, granulation tissue, vitreous

Feb 19 2019 by Lancaster Course in Ophthalmology

Ciliary processes are completely encased in organized scar tissue follow­ing an endophthalmitis. The posterior chamber is obliterated, and aqueous secretion has ceased. (H&E stain)

Condition/keywords: aqueous secretion, ciliary, endophthalmitis

Feb 19 2019 by Lancaster Course in Ophthalmology

Red-stained, round and cigar-shaped forms of the fungus Sporotrichum schenkii from chronic granuloma of the orbital margin. (PAS stain)

Condition/keywords: chronic granuloma, orbital margin, sporotrichum schenckii

Feb 19 2019 by Lancaster Course in Ophthalmology

Retinal granuloma in toxoplasmosis. Pink epithelioid cells and one giant cell are shown, surrounded by lymphocytes and plasma cells. (H&E stain)

Condition/keywords: epithelioid cells, granuloma, lymphocytes, toxoplasmosis

Feb 19 2019 by Lancaster Course in Ophthalmology

Large "mutton-fat" keratic precipitates composed of macrophages, lymphoeytes, and epithelioid cells in a granulomatous corneal ulcer. (H&E stain)

Condition/keywords: corneal ulcer, epithelioid cells, lymphocytes, macrophages

Feb 19 2019 by Lancaster Course in Ophthalmology

Langhans giant cell with peripheral nuclei in the reaction around a pool of fat, from a chalazion of the lid. (H&E stain)

Condition/keywords: chalazion, Langhans giant cell, nuclei

Feb 19 2019 by Lancaster Course in Ophthalmology

Touton giant cells in a xanthogranuloma of the lid. The mid-zone wreath of the nuclei and peripheral foamy cytoplasm are typical. (H&E stain)

Condition/keywords: cytoplasm, giant cell, nuclei, xanthogranuloma

Feb 19 2019 by Lancaster Course in Ophthalmology

Lymphocytes and macrophages around a vein ("cuffing") in the retina of a patient with endophthalmitis. (H&E stain)

Condition/keywords: endophthalmitis, lymphocytes, macrophages

Feb 19 2019 by Lancaster Course in Ophthalmology

Corneal graft following acute rejection. There is a diffuse infiltrate of lymphocytes and macrophages as well as vessel ingrowth. Donor stromal cells and parts of Bowman's membrane have been destroyed. (H&E stain)

Condition/keywords: Bowman's membrane, lymphocytes, macrophages, stroma

Feb 19 2019 by Lancaster Course in Ophthalmology

Perivascular eosinophils and PMNs in an acute conjunctivitis. (Giemsa stain)

Condition/keywords: acute conjunctivitis, perivascular eosinophils, polymorphonuclear leukocytes (PMNs)

Feb 19 2019 by Lancaster Course in Ophthalmology

Immune complex disease in the kidney. Upper left: Carcinoma of the the lung, source of an abnormal antigen. Upper right: Dense, gray antigen-antibody deposits around a capillary in a glomerulus. Lower left: Heavy fluorescent staining for comple­ment (C3) in a glomerulus. Lower right: Fluorescent staining for IgG, also positive. (Courtesy of David Jones, M.D., State University of New York, Upstate Medical Center, Syracuse.)

Condition/keywords: antigen-antibody deposits, glomerulus, IgG

Feb 19 2019 by Lancaster Course in Ophthalmology

Diagnostic buccal gland (lip) biopsy in Sjogren's syndrome. Upper: A normal gland with a few ducts and pale glandular acini. Lower: The glands are replaced by a lymphocytic infiltrate and the ducts are proliferating. An identical reaction occurs in the lacrimal glands. (H&E stain)

Condition/keywords: buccal gland, lacrimal glands, Sjogren's syndrome

Feb 19 2019 by Lancaster Course in Ophthalmology

Acute arteritis in an orbital inflammatory pseudotumor. Arterial wall is edematous and thickened with PMNs, lymphocytes, and macrophages. Eosinophils are seen in the tissue at right. (H&E stain)

Condition/keywords: arteritis, edematous, eosinophils, polymorphonuclear leukocytes (PMNs), pseudotumor

Feb 19 2019 by Lancaster Course in Ophthalmology

Large, granulomatous mass has eroded into the vitreous and retina from the sclera in Wegener's granulomatosis. Center shows pink caseous necrosis. (H&E stain)

Condition/keywords: sclera, vitreous, Wegener's granulomatosis

Feb 19 2019 by Lancaster Course in Ophthalmology

Smudgy, "fibrinoid" necrosis of collagen in the sclera of a patient with rheumatoid scleritis. Some abscess formation is seen above, rimmed by a granuloma­tous reaction. (H&E stain)

Condition/keywords: fibrinoid, sclera, scleritis

Feb 19 2019 by Lancaster Course in Ophthalmology

Swollen area of the inner retina contains a large perivascular nodule of cryptococcal organisms, resembling small red cells. Minimal lymphocytic reaction has occurred around the retinal vein. (PAS stain)

Condition/keywords: cryptococcal organisms, lymphocytes, perivascular nodule