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By Lancaster Course in Ophthalmology
1980 - Uploaded on Feb 26, 2019.
- Last modified by Caroline Bozell on Mar 8, 2019.
- Rating
- Appears in
- Unit 09 Pathology of the Retina
- Condition/keywords
- Bruch's membrane, drusen, serous retinal detachment, retinal pigment epithelium
- Description
- Ultrastructural appearance of Bruch's membrane and drusen material in eye with serous detachment of RPE. The RPE basement membrane is intact and normal (arrows). The inner collagenous zone of Bruch's membrane is greatly thickened (between larger arrows) by the accumulation of small vesicles, electron-dense particles, fibrils, and clusters of widely spaced collagen (large circle and inset). The middle-elastic layer of Bruch's membrane (small circle) is essentially normal. The outer collagenous zone (bracket) is mildly thickened with accumulation of material similar to that seen in the inner zone. Splitting of the thickened inner collagenous zone (asterisk) has occurred with the accumulation of a finely granular material, membranous structures, and electron-dense particles (CC =choriocapillaris).
