Twin Maps of Ischemia: A Fluorescein–OCT Angiography Mirror in Post-Transplant Vasculopathy

File number: 133826

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By Guilherme Sturzeneker, MD, MSc
Co-author(s): Gabriela Yea-Huey Yang, MD; Rubens Belfort Neto, MD, PhD; Rubens Belfort Junior, MD, PhD, MBA
Uploaded on Nov 13, 2025.
Last modified by Joshua Friedman on Nov 14, 2025.

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Appears in: 13-Nov-2025
Condition/keywords: Ischemic retinal vasculopathy, Hematopoietic stem cell transplantation, Non-graft-versus-host disease, Fluorescein angiography, OCT Angiography
Photographer: Patrick Oikawa, IPEPO - Instituto da Visão
Imaging device: Optical coherence tomography system
Intalight Dream OCT
Description: Fluorescein angiography (top) and optical coherence tomography angiography (bottom) from both eyes of a 29-year-old woman, obtained 49 days after haploidentical hematopoietic stem cell transplantation, demonstrating marked bilateral macular hypoperfusion with perivascular leakage. OCT-A confirms extensive capillary dropout in both eyes. These findings are consistent with atypical bilateral ischemic retinal vasculopathy unrelated to graft-versus-host disease. Management included oral corticosteroids and intravitreal anti-VEGF injections, with partial anatomical and functional response.