Cannula Tip Pressure

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File number: 132946

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    Appears in
    Miscellaneous
    Condition/keywords
    Leber's congenital amaurosis, retinitis pigmentosa, subretinal injection, gene therapy, genetic disorder
    Imaging device
    Leica Proveo 8
    Description
    Color stills from surgical videos of subretinal delivery of gene augmentation therapy with A) voretigene neparvovec-ryzl and B) laru-zova. In the left panel, the cannula is slightly bent, and the retina and RPE are blanched white around the cannula tip engagement. The bleb was challenging to form in this patient with advanced retinal degeneration, and the bleb is shallow and mostly clear. In the right panel, the cannula tip is gently engaged, the cannula is straight, and it follows the retinotomy as the retina is elevated by the injection fluid.

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