Search results (63 results)

May 3 2013 by Suber S. Huang, MD, MBA, FASRS

24-year-old male status post radiation for retinoblastoma with secondary metastatic carcinoma.

Imaging device: Retina Diseases Imaging Analysis Reading Center

Condition/keywords: endophytic tumor growth, intraocular tumor, macular lesion, radiotherapy, retinoblastoma

May 7 2019 by William Ensor

A 37-year-old female presented with a two-week history of vision loss in the right eye. She experienced a flu-like illness including rash on the hands, feet, and mouth 2 days prior to her vision change. Her 3-year-old son had a similar illness diagnosed as hand, foot, and mouth disease by his pediatrician one week prior. Her visual acuity was 20/150 of the right eye, and 20/20 of the left eye. On dilated fundus examination, the left eye was unremarkable; the right eye revealed a circular, variably pigmented lesion of the macula. OCT imaging showed areas of RPE loss and clumping, with overlying loss of the photoreceptor layer. Fluorescein angiography showed central and peripheral hyperfluorescence consistent with window defect, and blockage in area of RPE loss. No treatment was initiated at this time. The patient returned 10 days later; her visual acuity improved to 20/50 in the right eye. Dilated fundus exam showed increased pigmentation of the macular lesion. OCT of the right eye showed further RPE clumping without recovery of the photoreceptor layer, despite her improved visual acuity.

Condition/keywords: unilateral acute idiopathic maculopathy

Jun 2 2018 by awaneesh m upadhyay, MBBS, DNB

23-year-old patient's fundus photograph having complaints of defective vision, metamorphosia over 6 months shows yellow orange elevated well defined submacular lesion with normal overlying retinal vessels and normal disc . Vision left eye is 20/80.

Photographer: Hiteshwar Saikia

Condition/keywords: macular choroidal osteoma

Dec 18 2019 by Yoshihiro Yonekawa, MD, FASRS

Widefield fundus image of a teenage girl's right eye with an inactive congenital toxoplasmosis macular lesion. Her vision is 20/400 in this eye.

Photographer: Netanya Lerner, COA, Wills Eye Hospital/Mid Atlantic Retina

Imaging device: Optos California

Condition/keywords: congenital toxoplasmosis, pediatric retina

May 7 2019 by William Ensor

A 37-year-old female presented with a two-week history of vision loss in the right eye. She experienced a flu-like illness including rash on the hands, feet, and mouth 2 days prior to her vision change. Her 3-year-old son had a similar illness diagnosed as hand, foot, and mouth disease by his pediatrician one week prior. Her visual acuity was 20/150 of the right eye, and 20/20 of the left eye. On dilated fundus examination, the left eye was unremarkable; the right eye revealed a circular, variably pigmented lesion of the macula. OCT imaging showed areas of RPE loss and clumping, with overlying loss of the photoreceptor layer. Fluorescein angiography showed central and peripheral hyperfluorescence consistent with window defect, and blockage in area of RPE loss. No treatment was initiated at this time. The patient returned 10 days later; her visual acuity improved to 20/50 in the right eye. Dilated fundus exam showed increased pigmentation of the macular lesion. OCT of the right eye showed further RPE clumping without recovery of the photoreceptor layer, despite her improved visual acuity.

Condition/keywords: unilateral acute idiopathic maculopathy

Dec 10 2020 by McGill University Health Centre

Postmortem eyes from 101-year-old female. Past clinical history includes a poor vision for many years due to macular degeneration. The last visual acuity test recorded 6/15 OD and 6/6 OS. IOP 14 and 18 torr OS. Histopathology: Disclosed and yellow 2x2mm macular lesion. Microscopic examination: elevated placoid macular lesion with overlying pigment granules. Electron microscopy examination: pigment granules with abundant lipofuscin and melanolysosomes, photoreceptor cells markedly attenuated (less degenerated at the periphery) Numerous calcified drusen throughout the retina particularly in the posterior pole. RPE lipofuscin content is elevated in Best’s dystrophy. The extractability of the PRE lipofuscin fluorophores is reduced (it is normal during senescence). The defect in Best’s dystrophy accelerates this age related change in lipofuscin.

Condition/keywords: Best vitelliform macular dystrophy (BVMD), fundus photograph

Dec 10 2020 by McGill University Health Centre

Postmortem eyes from 101-year-old female. Past clinical history includes a poor vision for many years due to macular degeneration. The last Visual acuity test recorded 6/15 OD and 6/6 OS. IOP 14 and 18 torr OS. Histopathology: Disclosed and yellow 2x2mm macular lesion. Microscopic examination: elevated placoid macular lesion with overlying pigment granules. Electron microscopy examination: pigment granules with abundant lipofuscin and melanolysosomes, photoreceptor cells markedly attenuated (less degenerated at the periphery) Numerous calcified drusen throughout the retina particularly in the posterior pole. RPE lipofuscin content is elevated in Best’s dystrophy. The extractability of the PRE lipofuscin fluorophores is reduced (it is normal during senescence). The defect in Best’s dystrophy accelerates this age related change in lipofuscin.

Condition/keywords: Best vitelliform macular dystrophy (BVMD), histopathology, pathology

Dec 10 2020 by McGill University Health Centre

Postmortem eyes from 101-year-old female. Past clinical history includes a poor vision for many years due to macular degeneration. The last visual acuity test recorded 6/15 OD and 6/6 OS. IOP 14 and 18 torr OS. Histopathology: Disclosed and yellow 2x2mm macular lesion. Microscopic examination: elevated placoid macular lesion with overlying pigment granules. Electron microscopy examination: pigment granules with abundant lipofuscin and melanolysosomes, photoreceptor cells markedly attenuated (less degenerated at the periphery) Numerous calcified drusen throughout the retina particularly in the posterior pole. RPE lipofuscin content is elevated in Best’s dystrophy. The extractability of the PRE lipofuscin fluorophores is reduced (it is normal during senescence). The defect in Best’s dystrophy accelerates this age related change in lipofuscin.

Condition/keywords: Best vitelliform macular dystrophy (BVMD), histopathology, pathology

Dec 10 2020 by McGill University Health Centre

Postmortem eyes from 101-year-old female. Past clinical history includes a poor vision for many years due to macular degeneration. The last visual acuity test recorded 6/15 OD and 6/6 OS. IOP 14 and 18 torr OS. Histopathology: Disclosed and yellow 2x2mm macular lesion. Microscopic examination: elevated placoid macular lesion with overlying pigment granules. Electron microscopy examination: pigment granules with abundant lipofuscin and melanolysosomes, photoreceptor cells markedly attenuated (less degenerated at the periphery) Numerous calcified drusen throughout the retina particularly in the posterior pole. RPE lipofuscin content is elevated in Best’s dystrophy. The extractability of the PRE lipofuscin fluorophores is reduced (it is normal during senescence). The defect in Best’s dystrophy accelerates this age related change in lipofuscin.

Condition/keywords: Best vitelliform macular dystrophy (BVMD), histopathology, pathology

Jul 11 2013 by Jerald A. Bovino, MD

No history.

Condition/keywords: central vascular lesion, staphyloma

Apr 17 2025 by Gustavo Uriel Fonseca Aguirre

Top (B-mode): The longitudinal scan reveals a hyperechoic, flat, and well-demarcated macular lesion with posterior acoustic shadowing, pathognomonic for choroidal osteoma. Bottom (A-mode): Standardized tracing shows a tall initial spike (100% reflectivity) at the tumor surface with rapid decay to acoustic silence, confirming sound absorption by calcified tissue. This pattern remains unchanged at variable gain settings.

Photographer: Gustavo U. Fonseca Aguirre, Hospital Conde de Valenciana, Ciudad de México

Condition/keywords: choroidal osteoma, macular choroidal osteoma

Jan 21 2020 by Pierre-Henry Gabrielle, MD

Coupled OCT B-scan and IR imaging of a 17-year-old man with Combined hamartomas of the retina and retinal pigment epithelium (CHRRPE) at the posterior pole of the left eye. One can see a highly reflective elevated macular lesion with hyporeflective shadowing of the underlying tissue and obscuration of the normal retinal layers.

Photographer: Pierre-Henry Gabrielle, Ophthalmology department, Dijon University Hospital, France

Imaging device: Heidelberg Spectralis

Condition/keywords: combined hamartoma, optical coherence tomography (OCT)

Jan 21 2020 by Pierre-Henry Gabrielle, MD

Coupled OCT B-scan and IR imaging of a 17-year-old man with combined hamartomas of the retina and retinal pigment epithelium (CHRRPE) at the posterior pole of the left eye. One can see a highly reflective elevated macular lesion with hyporeflective shadowing of the underlying tissue and obscuration of the normal retinal layers.

Photographer: Pierre-Henry Gabrielle, Ophthalmology department, Dijon University Hospital, France

Imaging device: Heidelberg Spectralis

Condition/keywords: combined hamartoma, optical coherence tomography (OCT)

Aug 13 2013 by From the Collections of Thomas M. Aaberg, MD and Thomas M. Aaberg Jr., MD

Hyper and hypo oimentedmacular lesion.

Condition/keywords: congenital toxoplasmosis

Aug 13 2013 by From the Collections of Thomas M. Aaberg, MD and Thomas M. Aaberg Jr., MD

Hyper and hypo oimentedmacular lesion.

Condition/keywords: congenital toxoplasmosis

Aug 13 2013 by From the Collections of Thomas M. Aaberg, MD and Thomas M. Aaberg Jr., MD

Hyper and hypo oimentedmacular lesion.

Condition/keywords: congenital toxoplasmosis

Aug 13 2013 by From the Collections of Thomas M. Aaberg, MD and Thomas M. Aaberg Jr., MD

Hyper and hypo oimentedmacular lesion.

Condition/keywords: congenital toxoplasmosis

Aug 13 2013 by From the Collections of Thomas M. Aaberg, MD and Thomas M. Aaberg Jr., MD

Hyper and hypo oimentedmacular lesion.

Condition/keywords: congenital toxoplasmosis

Aug 13 2013 by From the Collections of Thomas M. Aaberg, MD and Thomas M. Aaberg Jr., MD

Hyper and hypo oimentedmacular lesion.

Condition/keywords: congenital toxoplasmosis

Aug 13 2013 by From the Collections of Thomas M. Aaberg, MD and Thomas M. Aaberg Jr., MD

Hyper and hypo oimentedmacular lesion.

Condition/keywords: congenital toxoplasmosis

Aug 13 2013 by From the Collections of Thomas M. Aaberg, MD and Thomas M. Aaberg Jr., MD

Hyper and hypo oimentedmacular lesion.

Condition/keywords: congenital toxoplasmosis

Aug 13 2013 by From the Collections of Thomas M. Aaberg, MD and Thomas M. Aaberg Jr., MD

Hyper and hypo oimentedmacular lesion.

Condition/keywords: congenital toxoplasmosis

Aug 13 2013 by From the Collections of Thomas M. Aaberg, MD and Thomas M. Aaberg Jr., MD

Hyper and hypo oimentedmacular lesion.

Condition/keywords: congenital toxoplasmosis

Aug 13 2013 by From the Collections of Thomas M. Aaberg, MD and Thomas M. Aaberg Jr., MD

Hyper and hypo oimentedmacular lesion.

Condition/keywords: congenital toxoplasmosis

Aug 13 2013 by From the Collections of Thomas M. Aaberg, MD and Thomas M. Aaberg Jr., MD

Hyper and hypo oimentedmacular lesion.

Condition/keywords: congenital toxoplasmosis