McGill University Health Centre » Ciliary Body Melanoma

May 18 2020 by McGill University Health Centre

Uveal melanoma is the most common primary eye malignancy in adulthood, occurring mainly after age 60. The uveal tract — composed of the iris, ciliary body, and choroid — can be affected by uveal melanoma. Despite advances in treatment of the primary tumor, metastatic disease occurs in almost half of patients, generally affecting the liver and lungs via hematogenous dissemination of the primary tumor. Tumors have different levels of pigmentation, and some are amelanocytic (nonpigmented). The differential diagnosis for amelanotic choroidal melanoma is metastatic disease. Large tumors displace the lens. Of the 3 locations in the uveal tract, tumors of the ciliary body have the worst prognosis. The enucleation specimen in (A) shows a firm, dome-shaped, deeply pigmented tumor arising from the ciliary body (arrow). The lens has been removed, and a diffuse retinal detachment artifact is present.

Condition/keywords: enucleation, melanoma

May 18 2020 by McGill University Health Centre

Uveal melanoma is the most common primary eye malignancy in adulthood, occurring mainly after age 60. The uveal tract — composed of the iris, ciliary body, and choroid — can be affected by uveal melanoma. Despite advances in treatment of the primary tumor, metastatic disease occurs in almost half of patients, generally affecting the liver and lungs via hematogenous dissemination of the primary tumor. Tumors have different levels of pigmentation, and some are amelanocytic (nonpigmented). The differential diagnosis for amelanotic choroidal melanoma is metastatic disease. Large tumors displace the lens. Of the 3 locations in the uveal tract, tumors of the ciliary body have the worst prognosis The enucleation specimen in (B) shows a large, dome-shaped, mixed melanotic and amelanotic choroidal melanoma. The anterior chamber is closed, and the angle is infiltrated (arrow). Total secondary retinal detachment with subretinal serous fluid and some subretinal hemorrhages are present (arrowhead). The lens is cataractous.

Condition/keywords: enucleation, melanoma

May 18 2020 by McGill University Health Centre

Uveal melanoma is the most common primary eye malignancy in adulthood, occurring mainly after age 60. The uveal tract — composed of the iris, ciliary body, and choroid — can be affected by uveal melanoma. Despite advances in treatment of the primary tumor, metastatic disease occurs in almost half of patients, generally affecting the liver and lungs via hematogenous dissemination of the primary tumor. Tumors have different levels of pigmentation, and some are amelanocytic (nonpigmented). The differential diagnosis for amelanotic choroidal melanoma is metastatic disease. Large tumors displace the lens. Of the 3 locations in the uveal tract, tumors of the ciliary body have the worst prognosis. This enucleation specimen shows a pigmented, nodular-shaped ciliary body melanoma (arrow) with extensive necrosis (*). A retinal detachment is present with subretinal fluid (arrowhead), and the retina is folded (•).

Condition/keywords: enucleation, melanoma

May 18 2020 by McGill University Health Centre

Large tumors displace the lens. Of the 3 locations in the uveal tract, tumors of the ciliary body have the worst prognosis. This enucleation specimen shows a pigmented, bilobed, dome-shaped tumor arising from the ciliary body (arrow). The lens has been removed, and a diffuse, flat retinal detachment artifact is present.

Condition/keywords: melanoma