Talhah - Zubair, MD » Miscellaneous

Dec 18 2025 by Talhah - Zubair, MD

16 year old girl with incidental mud splatter fundus in both eyes on exam, vision normal. Maternal grandmother and great-grandmother with cone-rod dystrophy. Maternal uncle with albinism and nystagmus. Mud splatter is most common in females who carry the gene for X-linked ocular albinism (OA Type 1). It is a patchy pattern of light and dark spots (hypo- and hyperpigmentation) seen in the peripheral retina, primarily in female carriers of the X-linked gene, caused by random inactivation of the X chromosome (Lyonization) during development. It appears as dark streaks against a bright background on fundus autofluorescence and indicates mosaicism, allowing carrier status to be identified even with normal vision.

Imaging device: Optos Silverstone

Condition/keywords: mud splattered, ocular albinism

Dec 18 2025 by Talhah - Zubair, MD

16 year old girl with incidental mud splatter fundus in both eyes on exam, vision normal. Maternal grandmother and great-grandmother with cone-rod dystrophy. Maternal uncle with albinism and nystagmus. Mud splatter is most common in females who carry the gene for X-linked ocular albinism (OA Type 1). It is a patchy pattern of light and dark spots (hypo- and hyperpigmentation) seen in the peripheral retina, primarily in female carriers of the X-linked gene, caused by random inactivation of the X chromosome (Lyonization) during development. It appears as dark streaks against a bright background on fundus autofluorescence and indicates mosaicism, allowing carrier status to be identified even with normal vision.

Imaging device: Optos

Condition/keywords: mud splatter, mud splattered, ocular albinism

Dec 18 2025 by Talhah - Zubair, MD

16 year old girl with incidental mud splatter fundus in both eyes on exam, vision normal. Maternal grandmother and great-grandmother with cone-rod dystrophy. Maternal uncle with albinism and nystagmus. Mud splatter is most common in females who carry the gene for X-linked ocular albinism (OA Type 1). It is a patchy pattern of light and dark spots (hypo- and hyperpigmentation) seen in the peripheral retina, primarily in female carriers of the X-linked gene, caused by random inactivation of the X chromosome (Lyonization) during development. It appears as dark streaks against a bright background on fundus autofluorescence and indicates mosaicism, allowing carrier status to be identified even with normal vision.

Imaging device: Optos Silverstone

Condition/keywords: carrier, mud splatter, mud splattered, ocular albinism

Dec 18 2025 by Talhah - Zubair, MD

16 year old girl with incidental mud splatter fundus in both eyes on exam, vision normal. Maternal grandmother and great-grandmother with cone-rod dystrophy. Maternal uncle with albinism and nystagmus. Mud splatter is most common in females who carry the gene for X-linked ocular albinism (OA Type 1). It is a patchy pattern of light and dark spots (hypo- and hyperpigmentation) seen in the peripheral retina, primarily in female carriers of the X-linked gene, caused by random inactivation of the X chromosome (Lyonization) during development. It appears as dark streaks against a bright background on fundus autofluorescence and indicates mosaicism, allowing carrier status to be identified even with normal vision.

Imaging device: Optos Silverstone

Condition/keywords: carrier, mud splattered, mud-splatter, mud-splattered, ocular albinism

Dec 18 2025 by Talhah - Zubair, MD

72 year old woman developed suprachoroidal hemorrhage during Yamane scleral intraocular lens fixation. At clinic follow up they were found to be appositional. Suprachoroidal tissue plasminogen activator was injected in clinic and an emergent choroidal cutdown drainage was performed the following day with subsequent resolution of apposition. Appositional choroidals were managed urgently to avoid retinal adhesion/membrane formation.

Condition/keywords: appositional choroidals, kissing choroidals, suprachoroidal hemorrhage

Dec 18 2025 by Talhah - Zubair, MD

72 year old woman developed suprachoroidal hemorrhage during Yamane scleral intraocular lens fixation. At clinic follow up they were found to be appositional. Suprachoroidal tissue plasminogen activator was injected in clinic and an emergent choroidal cutdown drainage was performed the following day with subsequent resolution of apposition. Appositional choroidals were managed urgently to avoid retinal adhesion/membrane formation.

Condition/keywords: appositional choroidals, kissing choroidals, suprachoroidal hemorrhage